Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling.

Chan Soon Park,Soo Hyun Kim,Hae Young Yang,Ju-Hee Kim,Ralph Theo Schermuly,Ye Seul Cho,Hyejeong Kang,Jae-Hyeong Park,Eunhyeong Lee, HyeonJin Park,Jee Myung Yang, Tae Wook Noh,Seung-Pyo Lee,Sun Sik Bae,Jinju Han,Young Seok Ju,Jun-Bean Park,Injune Kim

Circulation research（2022）

引用 12|浏览16

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摘要

The downregulation of Sox17 levels in pulmonary arterioles increases the susceptibility to PAH, particularly when exposed to hypoxia. Our findings suggest the reactive upregulation of HGF/c-Met signaling as a novel druggable target for PAH treatment.

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关键词

RNA,endothelial cells,hypoxia,pulmonary arterial hypertension,sequence analysis

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