Colla Corii Asini suppresses the atopic dermatitis-like skin lesions in NC/Nga mice and HaCaT keratinocytes

In traditional medicine, Colla Corii Anisi (donkey hide gelatin; CA) has been used to treat various diseases, such as anemia and gynecologic diseases, as well as strengthen blood and vital fluids. Despite the varied therapeutic efficacy and pharmacological effects of CA, its effects against atopic dermatitis (AD) have not yet been reported. We hypothesized that gelatin-rich CA alleviates AD-skin-like symptoms, preventing AD development and skin inflammation. We aimed to investigate the effect of CA on AD-like skin lesions and to determine the effective application of CA depending on different administration routes.