Traditional Chinese medicine promotes the resorption of herniated intervertebral discs by regulating autophagy and apoptosis

Feng Mao,Xiaoying Ma,Jingyun Chen,Hongwei Li,Zhijia Ma,Feng Dai,Baixue Xu,Jingtao Liu,Hong Jiang,Pengfei Yu

Pharmacological Research - Modern Chinese Medicine（2022）

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摘要

•Yiqi Huoxue Decoction induces the apoptosis and autophagy of human nucleus pulposus cells.•Yiqi Huoxue Decoction promotes the resorption and degeneration of ruptured intervertebral disc in rat.•Yiqi Huoxue Decoction mediates autophagy in human nucleus pulposus cells by ERK/mTOR signaling pathway.

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关键词

Yiqi Huoxue decoction,Lumbar disc herniation,Nucleus pulposus cells,Autophagy,Apoptosis,ERK/mTOR

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