Highly stable, non-toxic and functionalized nanoemulsion for the early diagnosis and amelioration of cancer

Ramesh Joga, Christy J Pulini-Kunnel,Chetan D Sabanis, Simran,Sandeep Kumar,Neeraj Kumar

PHARMACEUTICAL PATENT ANALYST(2022)

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摘要
Aim: To overcome the limitations associated with conventional formulations for cancer treatment by the effective utilization of nanoemulsion with therapy and diagnosis through the single unit. Patent: US20210275687 describes the usage of functionalized various oil-in-water nanoemulsions as pharmacological vehicles with theranostic potential in cancer treatment. Materials & methods: Vitamin E, oleic acid, sphingomyelin, ligands for functionalization, contrast agents and therapeutic biomolecules. Results: The toxicity studies conducted on healthy mice did not show any apparent toxicity issues. The stability studies conducted at 40 degrees C and 75% relative humidity, which is mandatory for regulatory approval, indicated the adequate physical stability of the formulation. Conclusion: The studies exhibited the promising theranostic potential of the developed nanoemulsion for the effective management and diagnosis of cancer and metastatic diseases.
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关键词
circulating tumor cells, contrast agents, functionalization, highly stable, ligands, metastasis, nanoemulsions, nanotheranostics, natural lipids, non-toxic
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