Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis

Cirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients' mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-based flow resistance analysis was proposed. The flow resistance analysis was performed for nine cirrhosis patients with CSPH and ten participants without liver diseases, respectively. The results showed that the flow resistance coefficient of the portal vein system in CSPH patients was significantly lower than that in the control group (0.97 +/- 0.11 Pa/(mL/s) for CSPH patients; 1.80 +/- 0.40 Pa/(mL/s) for the control group; P=0.028). In contrast, although main portal vein dilation was found in CSPH patients, the cross-sectional area enlargement was not statistically significant (186.01 & PLUSMN; 57.48 mm(2) for CSPH patients; 166.26 & PLUSMN; 33.74 mm(2) for the control group; P=0.39). The research outcomes indicated that the flow resistance analysis was more sensitive than the commonly used vessel size measurement in the detection of CSPH. In summary, we suggest using flow resistance analysis as a supplementary noninvasive method to detect cirrhosis patients with CSPH.