Belimumab use during pregnancy: a summary of birth defects and pregnancy loss from belimumab clinical trials, a pregnancy registry and postmarketing reports.

Michelle Petri,Helain Landy,Megan E B Clowse,Kim Gemzoe,Munther Khamashta,Milena Kurtinecz,Roger A Levy,Andrew Liu,Rebecca Marino,Paige Meizlik,Jeanne M Pimenta,Kelsey Sumner,Hugh Tilson, Mary Beth Connolly,Keele Wurst,Julia Harris,Holly Quasny,Patricia Juliao,David A Roth

Annals of the rheumatic diseases（2023）

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摘要

Observations reported here add to limited data published on pregnancy outcomes following belimumab exposure. Low numbers of exposed pregnancies, presence of confounding factors/other biases, and incomplete information preclude informed recommendations regarding risk of birth defects and pregnancy loss with belimumab use.

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Autoimmune Diseases,Biological Therapy,Lupus Erythematosus, Systemic

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