Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands

Angelina Yu. Bobrova,Maxim A. Novikov,Roman A. Novikov,Pavel V. Dorovatovskii,Alexander D. Volodin,Alexander A. Korlyukov,Yury V. Tomilov

Mendeleev Communications（2022）

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摘要

The key enantioselectivity-determining step in Pd-catalyzed asymmetric amination of 2-fluoroallylic substrates was optimized using model reaction of η3-(2-fluorocycloheptenyl)-palladium complexes bearing chiral P,P- and P,N-ligands with various amines. (S)-ButPHOX was found to be the most effective ligand allowing the formation of 2-fluoroallyl amines and anilines with high enantioselectivity.

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关键词

fluoroalkenes,2-fluoroallyl amines,enantioselective catalysis,chiral palladium complexes,allylic amination

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