Abnormal neural differentiation in response to graphene quantum dots through histone modification interference

Tingting Ku,Zhihua Ren,Renjun Yang,Qian S. Liu,Nan Sang,Francesco Faiola,Qunfang Zhou,Guibin Jiang

Environment International（2022）

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摘要

•OH-GQDs inhibited the ectoderm development of the mESCs.•Exposure to OH-GQDs reduced the neural precursor formation and neurogenesis.•OH-GQDs selectively affected BMP pathway by disturbing histone modification.•OH-GQDs elicited higher hazards on neurodevelopment than did NH2-GQDs.

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关键词

Graphene quantum dots,Embryonic stem cells,Neural differentiation,BMP signaling pathway,Histone modification

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