Tim-3 blockade enhances the clearance of Chlamydia psittaci in the lung by promoting a cell-mediated immune response

Zhenyu Li,Yan Wang,Kang Zheng, Xianzhou Lu,Zhangping He,Siqin He,Yumeng Li,Dingxin Long

International Immunopharmacology（2023）

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摘要

•Expression of Tim-3+ T cells is increased and proportion of T cells are reduced in mice infected with C. psittaci.•Blockage of Tim-3 signaling is effective against C. psittaci infection via increase IFN-γ/Th17 immuneresponse.•Blocking Tim-3 signaling/neutralization of IFN-γ or blocking Tim-3 signaling/neutralization of IL17A failed to protect against C. psittaci infection.

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关键词

Chlamydia psittaci,Tim-3,Th1/Th17,Tregs,Immune response

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