Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep

Jie Du,João P. Garcia,Frances C. Bach,Anna R. Tellegen,Sibylle Grad,Zhen Li,René M. Castelein,Björn P. Meij,Marianna A. Tryfonidou,Laura B. Creemers

Journal of Orthopaedic Translation（2022）

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摘要

The contradictory results of using BMP-4 on IVD regeneration between and demonstrate that direct BMP-4 injection for disc degeneration-associated human chronic low back pain should not be undertaken. In addition, our results may also shed light on the mechanisms behind pathological endplate changes in human patients as a possible target for therapy.

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关键词

BMP-4,Intervertebral disc regeneration,Nucleus pulposus,Annulus fibrosus,Subchondral bone remodeling,Bone formation

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