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Age‐dependent effects of diabetes and obesity on liver‐related events in nonalcoholic fatty liver disease: Subanalysis of CLIONE in Asia

Yuya Seko,Miwa Kawanaka,Hideki Fujii,Michihiro Iwaki,Hideki Hayashi,Hidenori Toyoda,Satoshi Oeda,Hideyuki Hyogo,Asahiro Morishita,Kensuke Munekage,Kazuhito Kawata,Sakura Yamamura,Koji Sawada,Tatsuji Maeshiro,Hiroshi Tobita,Yuichi Yoshida,Masafumi Naito,Asuka Araki,Shingo Arakaki,Takumi Kawaguchi,Hidenao Noritake,Masafumi Ono,Tsutomu Masaki,Satoshi Yasuda,Eiichi Tomita,Masato Yoneda,Akihiro Tokushige,Yoshihiro Kamada,Hirokazu Takahashi,Shinichiro Ueda,Shinichi Aishima,Yoshio Sumida,Takeshi Okanoue,Yoshito Itoh,Atsushi Nakajima

Journal of Gastroenterology and Hepatology（2022）

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摘要
Type 2 diabetes mellitus and obesity contributed to LRE in younger and older patients, respectively, along with advanced fibrosis. Therefore, controlling T2DM in patients younger than 65 years and controlling weight in patients 65 years and older could prevent LRE. The development of age-dependent screening and management strategies is necessary for patients with NAFLD.
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关键词
BMI,CLIONE in Asia,age,fibrosis,hepatocellular carcinoma,liver-related events,non-alcoholic fatty liver disease,non-alcoholic steatohepatitis,obesity,type 2 diabetes mellitus
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