The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization

Parisa Dashti,Jeroen van de Peppel,Roman Thaler,Christopher R Paradise,Gary S Stein,Martin A Montecino,Johannes P T M van Leeuwen,Bram J van der Eerden,Amel Dudakovic,Andre J van Wijnen

Gene（2023）

引用 3|浏览34

暂无评分

摘要

•Smyd2 is the most prominently expressed Smyd mRNA in human bone tissue and mouse osteoblasts.•Smyd2 is a lysine methyltransferase that modifies both histone and non-histone proteins.•Smyd2 depletion stimulates osteoblast proliferation in MC3T3 cells.•Smyd2 loss increases Ezh2 protein expression.•Loss of both Smyd2 and Ezh2 promotes osteoblast mineralization in MC3T3 cells.

查看译文

关键词

Bone,Osteoblast,Osteogenesis,Epigenetics,Chromatin,Histone,Mineralization

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要