Effects of low and high factor X concentrations on thrombin generation in vitro

Ryui Miyashita,Keiko Shinozawa,Eisuke Takami, Koichi Ohkuma,Kagehiro Amano

Thrombosis Update（2022）

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摘要

•FX caused concentration-dependent changes in TG in hemophilia plasma models.•Adding FVIIa/FX normalized thrombin levels under low FX concentrations.•TG increases with FX concentrations up to 10 IU/mL.•Bypass hemostatic therapy with FX may be effective under low plasma FX levels.•The risk of overcoagulation under high plasma FX levels may be low.

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关键词

Factor X,Factor VIIa,Hemophilia,Bypassing agents,Thrombin generation,aPTT

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