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Preclinical Characterization of Amubarvimab and Romlusevimab, a Pair of Non-Competing Neutralizing Monoclonal Antibody Cocktail, Against SARS-CoV-2

Yun Ji,Qi Zhang,Lin Cheng,Jiwan Ge,Ruoke Wang,Mengqi Fang,Eric M. Mucker,Peng Chen,Ji Ma,Rui Zhang,Chunming Li,Holly Hammond,Lauren Baracco,Michael Holbrook,Matthew Frieman,Zheng Zhang,Xinquan Wang,Jay W. Hooper,Linqi Zhang,Qing Zhu

Frontiers in Immunology（2022）

Cited 12|Views51
Key words
monoclonal antibody (mAb),severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),receptor binding domain (RBD),M252Y,S254T,T256E (YTE),amubarvimab (BRII-196),romlusevimab (BRII-198),variant of concern (VOC),half-maximal inhibitory concentration (IC50)
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