Microglial response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice after systemic stimulation with Escherichia coli

Inge C M Hoogland,Jutka Yik,Dunja Westhoff,Joo-Yeon Engelen-Lee,Merche Valls Seron,Wing-Kit Man,Judith H P M Houben-Weerts,Michael W Tanck,David J van Westerloo,Tom van der Poll,Willem A van Gool,Diederik van de Beek

Neuroscience Letters（2022）

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摘要

•Loss of function of TREM2 during systemic infection leads to an increased number of microglial cells in thalamus after inoculation.•Loss of function of TREM2 during systemic infection does not lead to increased expression of pro-inflammatory genes in the brain.•The role of TREM2 in the neuro-inflammatory response following systemic infection appears to be limited in our experiments.

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7-AAD,A20,ADP,APC,ATP,°C,CA1,CD11b,CD14,CD16,CD32,CD45,cDNA,CFU,CI,CNS,CSF,deltaCt,E. coli,GABA,geoMFI’s,GFAP,GKN-BSA,HE,HMGB1,Iba-1,IL-1β,IL-6,IL-12,IQR,IVC,LB,LPS,MAPK1,MCP-1,M-CSF,mRNA,NoNo,PBS,PE,PerCP,qPCR,RNA,SOCS1,TGF-β,TLR,TLR-2,TNF-α

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