Age of onset for major depressive disorder and its association with symptomatology

•We used machine learning and latent profile analysis to investigate the relationship between symptomatology and age of onset.•Symptom profiles are closely associated with age of onset.•Age of onset is positively associated with neurovegetative symptom severity.•Age of onset is negatively associated with cognitive-behavioral symptom severity.•Individuals in subgroups characterized by suicide and guilt have an earlier age of onset.