Investigation on conformational variation and enzymatic activity of trypsin affected by Ti3C2 QDs via spectroscopic technique and molecular modeling

Qi Xiao,Huajian Luo,Huishan Cao,Bo Li,Jiajia Liu,Yi Liu,Shan Huang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2023）

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摘要

•Binding interaction between Ti3C2 QDs and trypsin was systematically investigated.•Ti3C2 QDs bound with trypsin and statically quenched its inherent fluorescence.•Ti3C2 QDs efficiently inhibited the enzymatic activity of trypsin on HSA digestion.•Ti3C2 QDs exhibited potentials in the diagnosis and therapy of serious protease-related diseases.

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关键词

Protease,Ti3C2 quantum dots,Conformational variation,Enzymatic activity,Cells digestion

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