Emulating the GRADE trial using real world data: retrospective comparative effectiveness study.

Yihong Deng,Eric C Polley,Joshua D Wallach,Sanket S Dhruva,Jeph Herrin,Kenneth Quinto,Charu Gandotra,William Crown,Peter Noseworthy,Xiaoxi Yao,Timothy D Lyon,Nilay D Shah,Joseph S Ross,Rozalina G McCoy

BMJ (Clinical research ed.)（2022）

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摘要

In this emulation of the GRADE trial, liraglutide was statistically significantly more effective at maintaining glycemic control than glimepiride or sitagliptin when added to metformin monotherapy. Generating timely evidence on medical treatments using real world data as a complement to prospective trials is of value.

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