The correlation between pre-treatment symptoms, acute and late toxicity and patient-reported health-related quality of life in non-small cell lung cancer patients: Results of the REQUITE study

•Pre-treatment symptoms impact HRQoL and its functional domains in NSCLC.•After radiotherapy, overall and specific toxicities impact HRQoL and its domains.•Dyspnoea as symptom and toxicity is crucial in this association with HRQoL.•Toxicity after concurrent chemo-radiotherapy and 3D-CRT most negatively affects HRQoL.•It is important to limit radiation-induced toxicity to ensure HRQoL in NSCLC.