Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation

Honggui Li,Juan Zheng,Qian Xu,Yongjian Yang,Jing Zhou,Xinlei Guo,Yongfeng Cai,James J Cai,Linglin Xie,Joseph Awika,Xianlin Han,Qingsheng Li,Lindsey Kennedy,Heather Francis,Shannon Glaser,Yuqing Huo,Gianfranco Alpini,Chaodong Wu

Gastroenterology（2023）

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摘要

Hepatocyte ADK functions to promote excessive fat deposition and liver inflammation through suppressing hepatocyte fatty acid oxidation and producing hepatocyte-derived proinflammatory mediators. Therefore, hepatocyte ADK is a therapeutic target for managing obesity and nonalcoholic fatty liver disease.

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关键词

Insulin Resistance,Mitochondrial DNA

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