P21 deficiency exhibits delayed endochondral ossification during fracture healing.

Kenichi Kikuchi,Masahiko Haneda,Shinya Hayashi,Toshihisa Maeda,Naoki Nakano,Yuichi Kuroda,Masanori Tsubosaka,Tomoyuki Kamenaga,Masahiro Fujita,Kenmei Ikuta,Kensuke Anjiki,Shotaro Tachibana,Yuma Onoi,Tomoyuki Matsumoto,Ryosuke Kuroda

Bone（2022）

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摘要

p21 deficiency leads to delayed endochondral ossification by attenuating the Ihh-Runx2-Osterix pathway in vivo, and p21 deficiency in hypertrophic chondrocytes causes delayed differentiation of hypertrophic chondrocytes in vitro. p21 plays a role in endochondral ossification during fracture healing.

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关键词

Endochondral ossification,Fracture healing,Tibia fracture,p21

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