Agreement between parents' and clinical researchers' ratings of behavioral problems in children with fragile X syndrome and chromosome 15 imprinting disorders

Marta Arpone,Lesley Bretherton,David J. Amor,Stephen J.C. Hearps,Carolyn Rogers,Michael J. Field,Matthew F. Hunter,Lorena Santa Maria,Angelica M. Alliende,Jennie Slee,David E. Godler,Emma K. Baker

Research in Developmental Disabilities（2022）

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摘要

•Lack of appropriate outcome measures has contributed to failed clinical trials.•Parents’ and researchers’ appraisal of hyperactivity showed the greatest agreement.•Appraisal of self-injury showed the poorest agreement.•A multi-informant approach would benefit clinical trials for children with NDDs.

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关键词

Fragile X syndrome,Angelman syndrome,Prader-Willi syndrome,Dup15q syndrome,ABC-C,ADOS-2

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