Zellspezifische Produktion von multiplen Therapeutika im Körper

Many conventional cancer therapies suffer from side effects and low efficacy, due to poor tumor localization of systemically injected therapeutics. Utilizing the adenoviral SHREAD platform, therapeutic genes were delivered specifically to cancer cells in vivo that express a defined, freely selectable cell receptor. Antibodies secreted by infected cells were visualized using a cell-clearing technology, revealing a high local concentration of the antibody within the tumor, with minimal concentration in peripheral healthy tissues.