Produktion von Aminosäurederivaten in Cyanobakterien

As photolithoautotrophs, cyanobacteria are key to a future photobiotechnology. We studied the capacity of Synechocystis sp. PCC 6803 to produce trans-4-hydroxy-L-proline, a valuable chiral synthon using oxygenic photosynthesis and a recombinant L-proline-4-hydroxylase. At scale, such a process would use comparable area of land to a heterotrophic one if the photosynthesis of sugar is also considered. Phototrophs offer a huge potential for higher production rates and product titers.