The effect of pNaSS grafting of knitted poly(ε-caprolactone) artificial ligaments on in vitro mineralization and in vivo osseointegration

Emeline Maurice,André Luiz Reis Rangel,Jagadeesh K Venkatesan,Amélie Leroux,Hanane El Hafci,Diane Pichard,Mathieu Manassero,Thibault Godineau,Julie Vial,Gertrud Schmitt,Susanne Speicher-Mentges,Marie Vandesteene,Magali Cucchiarini,Véronique Migonney,Véronique Viateau

Materialia（2022）

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摘要

Augmenting anterior cruciate ligament (ACL) repair using synthetic scaffolds to promote ligament healing is a new emerging surgical strategy for the treatment of ruptured ACL. Osseointegration of such scaffolds is critical, as the lack of osseointegration may lead to bone tunnel widening and joint instability.

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关键词

Biodegradable polymers,Artificial ligaments,Surface functionalization,Osseointegration,Cell culture,Animal model,Bioactivity

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