CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients

Chiara Dalle Fratte,Sara Gagno,Rossana Roncato,Jerry Polesel,Martina Zanchetta,Mauro Buzzo,Bianca Posocco,Elena De Mattia,Rachele Borsatti,Fabio Puglisi,Luisa Foltran,Michela Guardascione,Angela Buonadonna,Erika Cecchin,Giuseppe Toffoli

British journal of clinical pharmacology（2023）

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摘要

These findings highlight that CYP2D6 plays a major role in imatinib pharmacokinetics, but other players (i.e., CYP2C8) may influence imatinib exposure. These findings could drive the selection of patients more susceptible to imatinib under- or overexposure who could be candidates for personalized treatment and intensified monitoring strategies.

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关键词

CYP2C8,CYP2D6,GIST,imatinib,pharmacogenetics

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