Sea urchin-like Bi 2 S 3 /curcumin heterojunction rapidly kills bacteria and promotes wound healing under near-infrared light.

Bacterial infection is an urgent public health problem. We design a novel photo-responsive hybrid material by growing small molecules of curcumin (Cur) on a sea urchin-like BiS surface by a one-step hydrothermal reaction method, thus forming an organic-inorganic hybrid material with interfacial contact. The BiS/Cur hybrid material has good antibacterial effect under 808 nm near-infrared (NIR) light irradiation. The antibacterial mechanism is that the electron redistribution at the interface of BiS/Cur excited by 808 nm NIR light will cause a large number of electrons to gather on the side of BiS, forming an internal electric field to drive the excited electrons from BiS to Cur, which accelerates the separation of photoexcited electron-hole pairs and enhances the production of reactive oxygen species (ROS). In conclusion, due to these synergistic effects of the photothermal properties of BiS, the production of more ROS and the release of small molecules of Cur from traditional Chinese medicine in BiS/Cur, the antibacterial efficacy against () and () is 99.96% and 99.03%, respectively. experiments in animals show that BiS/Cur can reduce the inflammatory response and promote wound healing. This paper presents a simple, rapid and safe strategy for the treatment of wound infections with near-infrared light.