Perioperative stress prolong post-surgical pain via miR-339-5p targeting oprm1 in the amygdala.

Yi Zhu, Mei Sun,Peng Liu,Weidong Shao, Ming Xiong,Bo Xu

The Korean journal of pain(2022)

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摘要
Perioperative stress could increase the expression of miR-339-5p, and miR-339-5p could cause the expression of MOR to decrease via targeting . This regulatory pathway maybe an important molecular mechanism of CPSP.
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关键词
Amygdala,Animal,Glucocorticoids,MicroRNAs,Models,Opioid,Pain,Pain Perception,Physiological.,Physiopathology,Postoperative,Receptors,Stress,mu
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