Effects of SativexⓇ on cognitive function in patients with multiple sclerosis: A systematic review and meta-analysis

•Cognitive impairment is a common manifestation of multiple sclerosis.•Exposure to cannabis is also associated with dose-related cognitive impairment.•We assessed whether therapeutic use of nabiximols impacted cognition in MS patients.•Evidence suggests that nabiximols has no detrimental effects on cognitive function.•Cognitive adverse events are rare and occurred only during not in-label use.