Individual- and school-level patterns of substance use and mental health symptoms in a population-based sample of secondary students: A multilevel latent profile analysis

•5 substance use and mental health symptom profiles identified among adolescents.•3 types of schools were found with varying levels of student comorbidity.•School climate, belonging, and safety appeared protective.•Substance use and mental health concerns should be considered concurrently.•Schools are important contexts for addressing student substance use and comorbidity.