How sugar instigates macrophages to be evils in tumor

In a recent issue of the journal Cancer Cell,Shi et al.reported that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and chemoresistance.Mechanistically,the consump-tion of glucose fuels hexosamine biosynthetic pathway(HBP)and enhances O-GlcNAcylation of Cathepsin B in macrophages,which upon secretion disrupts the tumor microenvironment(TME)[1].