Predictive Modeling of Huntington's Disease Unfolds Thalamic and Caudate Atrophy Dissociation.

Eduardo Castro,Pablo Polosecki,Dorian Pustina,Andrew Wood,Cristina Sampaio,Guillermo A Cecchi

Movement disorders : official journal of the Movement Disorder Society（2022）

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摘要

This study is the first attempt to validate before-CMD multivariate subcortical change detection across studies and to do multivariate prospective atrophy prediction in HD. These models achieve improved performance by detecting a dissociation between caudate and thalamic atrophy trajectories, and they provide a possible mechanistic understanding of the dynamics of HD. © 2022 International Parkinson and Movement Disorder Society.

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关键词

Huntington's disease,multistudy validation,multivariate,subcortical,thalamus

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