Oviductal Glycoprotein 1 Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction With MYH9.

Congxia Bai,Ming Su,Yaohua Zhang,Yahui Lin,Yingying Sun,Li Song,Ning Xiao,Haochen Xu,Hongyan Wen,Meng Zhang,Jiedan Ping,Jing Liu,Rutai Hui,Hao Li,Jingzhou Chen

Circulation（2022）

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摘要

Hypomethylation at cg20823859 in the promoter region of is associated with hypertension and induces upregulation of OVGP1. The interaction between OVGP1 and MYH9 contributes to vascular remodeling and dysfunction. Therefore, OVGP1 is a prohypertensive factor that promotes vascular remodeling by binding with MYH9.

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关键词

DNA methylation,hypertension,vascular remodeling

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