Characterization of a macrophagic-like cell line derived from rabbit fish (Siganus fuscescens): An illustration of anti-inflammatory responses of the herbal extract of Scutellaria baicalensis

•A new macrophage cell line divided from siganus fuscescens was established and named as RFM cell.•The RFM cell exhibited sensitive responses to LPS-induced inflammation and identified as M1 type macrophage cell.•The aerial part of S. baicalensis extract and it's two effective compounds showed anti-inflammatory effect on RFF cell, indicating the potential application as an aquaculture feeding additive.