Cell/Surface Interactions and the Integrity of Ti-6AI-4V Structures: Effects of Surface Texture and RGD Coatings

This article presents comprehensive insights and a review of cell/surface interactions on Ti-6AI-4V surfaces that are relevant to biomedical implants. The effects of surface texture are discussed for the development of biomedical implants for applications in orthopedics and dentistry. These include textured screws that have been developed along with Arginine Glycine Aspartate (RGD)-coated surfaces to enable improved osseointegration and robustness of interfaces between Ti-6Al-4V surfaces and bone cells/tissues. Following an initial review of cell-surface interactions in in-vitro studies, the results of in-vivo animal studies/human trials are presented. Measurements of adhesion and interfacial robustness are also presented before discussing their implications for the development of robust RGD-coated and textured biomedical Ti-6Al-4V surfaces.