Novel lipid emulsion for total parenteral nutrition based on 18-carbon n-3 fatty acids elicits a superior immunometabolic phenotype in a murine model compared with standard lipid emulsions.

Eliana Lucchinetti,Phing-How Lou,Gregory Holtzhauer,Nazek Noureddine,Paulina Wawrzyniak,Ivan Hartling,Megan Lee,Erin Strachan,Xavier Clemente-Casares,Sue Tsai,Gerhard Rogler,Stefanie D Krämer,Martin Hersberger,Michael Zaugg

The American journal of clinical nutrition（2022）

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摘要

We here report the unique anti-inflammatory, insulin-sensitizing, and immunity-enhancing properties of a newly developed lipid emulsion designed for TPN use based on 18-carbon n-3 fatty acids.

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关键词

18-carbon n–3 fatty acids,CD4+ T cells,gut microbiome,insulin receptor substrate 2,interleukin-10,lipid mediators,macrophages,stearidonic acid,total parenteral nutrition,α-linolenic acid

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