Luteolin alleviates ulcerative colitis by restoring the balance of NCR-ILC3/NCR+ILC3 to repairing impaired intestinal barrier

Xueqian Xie,Meng Zhao,Shaowei Huang, Pengcheng Li, Peiqi Chen,Xia Luo,Qing Wang,Zengfeng Pan,Xiangling Li,Jinyan Chen,Bin Chen,Lian Zhou

International Immunopharmacology（2022）

引用 4|浏览4

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摘要

•Luteolin restores intestinal barrier structure and function in UC mice.•Luteolin regulates ILC3 plasticity, which is the key to maintaining intestinal homeostasis.•Luteolin restores NCR-ILC3/NCR+ILC3 balance through the Notch pathway.

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关键词

Luteolin,Ulcerative colitis,NCR+ILC3,Notch pathway,Intestinal barrier

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