BMPR1A Promotes ID2-ZEB1 Interaction to Suppress Excessive Endothelial to Mesenchymal Transition.

Heon Woo Lee,Takaomi Adachi,Boryeong Pak,Saejeong Park,Xiaoyue Hu,Woosoung Choi,Piotr S Kowalski,C Hong Chang, Katharine R Clapham,Aram Lee,Irinna Papangeli,Jongmin Kim,Orjin Han,Jihwan Park,Daniel G Anderson,Michael Simons,Suk Won Jin,Hyung J Chun

Cardiovascular research（2022）

引用 5|浏览25

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摘要

We demonstrate that BMPR1A is key to maintain endothelial identity and to prevent excessive EndoMT. We identify BMPR1A-induced interaction between ID2 and ZEB1 is the key regulatory step for onset of EndoMT and pathogenesis of PAH. Our findings indicate that BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potential novel therapeutic target for PAH and other EndoMT-related vascular disorders.

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关键词

BMP signaling,BMPR1A,EndoMT,pulmonary arterial hypertension,vascular remodeling

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