The fibrotic niche impairs satellite cell function and muscle regeneration in mouse models of Marfan syndrome.

Meiricris Tomaz da Silva,Audrei R Santos,Tatiana E Koike,Tabata L Nascimento,Andrei Rozanski,Darko Bosnakovski,Lygia V Pereira,Ashok Kumar,Michael Kyba,Elen H Miyabara

Acta physiologica (Oxford, England)（2023）

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摘要

The fibrotic niche, caused by Fbn1 mutations, reduces the myogenic potential of satellite cells, affecting structural and functional muscle regeneration. In addition, the fibrosis inhibitor Ang-(1-7) partially counteracts satellite cell abnormalities and restores myofiber size and contractile force in regenerating muscles.

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关键词

Marfan syndrome,angiotensin-1-7,fibrosis,satellite cell function,skeletal muscle regeneration

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