Protease‐ and cell type–specific activation of protease‐activated receptor 2 in cutaneous inflammation

Maria Isabel Fleischer,Nadine Röhrig,Verena K Raker, Juliane Springer,Detlef Becker, Sandra Ritz,Matthias Bros,Henner Stege,Maximilian Haist,Stephan Grabbe, Jessica Haub,Christian Becker,Sabine Reyda,Jennifer Disse, Talkea Schmidt,Karsten Mahnke,Hartmut Weiler,Wolfram Ruf,Kerstin Steinbrink

Journal of Thrombosis and Haemostasis（2022）

引用 2|浏览21

暂无评分

摘要

Myeloid cells infiltrate the skin in contact hypersensitivity (CHS) and promote skin inflammation through protease activated receptor (PAR) 2 signaling. PAR2 mutants with resistance to selective proteases implicate coagulation FXa as a driver for the persistence of inflammation after allergen challenge. Pharmacological inhibitions indicate that the TF‐FXa‐PAR2 axis is a potential therapeutic target in CHS.Unlabelled Image

查看译文

关键词

allergic contact dermatitis,contact hypersensitivity,factor Xa,protease‐activated receptor 2,tissue factor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要