Serological profiling of Crohn's disease and ulcerative colitis patients reveals anti-microbial antibody signatures.

Mahasish Shome,Lusheng Song,Stacy Williams,Yunro Chung,Vel Murugan,Jin G Park,William Faubion,Shabana F Pasha,Jonathan A Leighton,Joshua LaBaer,Ji Qiu

World journal of gastroenterology（2022）

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摘要

We have identified antibody signatures for CD and UC using a comprehensive analysis of anti-microbial antibody response in IBD. These antibodies and the source microorganisms of their target antigens improve our understanding of the role of specific microorganisms in IBD pathogenesis and, after future validation, should aid early and accurate diagnosis of IBD.

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关键词

Anti-microbial antibody,Crohn’s disease,Gut microbiome,Inflammatory bowel disease,Protein microarray,Ulcerative colitis

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