Cytochrome P450 Genes Mediated by DNA Methylation Are Involved in the Resistance to Hidradenitis Suppurativa.

Hidradenitis suppurativa (HS) is a recurrent inflammatory skin condition starting in the pilosebaceous unit and then progressing as a systemic inflammatory disease with a wide range of comorbidities ( Conic et al., 2021 Conic R.R.Z. Fabbrocini G. Marasca C. Bragazzi N.L. Watad A. Adawi M. et al. Burden of ocular comorbidities in patients with hidradenitis suppurativa. JAMA Dermatol. 2021; 157: 226-227 Crossref PubMed Scopus (7) Google Scholar ). Currently, there is no definitive cure for HS, and available treatments aim only to manage/limit disease flares. The cytochrome P450 (CYPs) enzymes are crucial for the metabolism of drugs ( Habano et al., 2015 Habano W. Kawamura K. Iizuka N. Terashima J. Sugai T. Ozawa S. Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes. Clin Epigenetics. 2015; 7: 105 Crossref PubMed Scopus (39) Google Scholar ), thus variations in CYP enzymes can lead to skin diseases, metabolic syndromes, depression, suicidal ideation, substance abuse, addiction, and chronic pain ( Höfer et al., 2013 Höfer P. Schosser A. Calati R. Serretti A. Massat I. Kocabas N.A. et al. The impact of cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2013; 263: 385-391 Crossref PubMed Scopus (15) Google Scholar ; Tennant, 2015 Tennant F. Opioid regimens in patients with chronic pain with multiple cytochrome P450 defects. J Opioid Manag. 2015; 11: 237-242 Crossref PubMed Scopus (2) Google Scholar ). This study aimed to examine whether differences in CYPs methylation between HS and controls contribute to HS resistance.