Deciphering a novel chloramphenicols resistance mechanism: Oxidative inactivation of the propanediol pharmacophore

Jiayu Zhang,Chao Yang,Jiahui Hu,Yiting Zhang,Yuezheng Lai,Hongri Gong,Fangliang Guo,Xiaoyan Li,Lin Ye,Bing Li

Water Research（2022）

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摘要

•An oxidoreductase capO confers chloramphenicols resistances in bacteria.•capO catalyzes a four-electron double oxidation reaction on the C3-OH group.•Association with type IV secretion system confers potential mobility of capO.•Chloramphenicols pollution is the crucial driving factor for capO development.

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关键词

Chloramphenicols,Antibiotic resistance gene,Oxidative inactivation,Comparative proteomics,Metagenomics, Heterologous expression

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