Pan‐cancer landscape of abnormal ctDNA methylation across human tumors

Yun Bai,Di Qu,Dan Lu,Yiwen Li,Ning Zhao,Guanghua Cui,Xue Li,Xiaoke Sun,Huaibo Sun,Lihua Zhao,Qingyuan Li,Qi Zhang,Tiancheng Han, Song Wang,Yu Yang

Cancer Genetics（2022）

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摘要

•ctDNA methylation level is abnormally high in cancer patients.•Methylation burden is clearly related to TMB, MSI and PD-L1.•ctDNA methylation is related to the type, frequency and number of mutations.

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关键词

Circulating tumor DNA,Epigenetics,Pathway,Methylation model,Pan-cancer analysis

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