A novel method for in vitro culture and expansion of nonhuman primate B cells

Isabel DeLaura,Paul M Schroder,Janghoon Yoon,Joseph Ladowski,Imran J Anwar,Brian Ezekian,Robin Schmitz,Zachary W Fitch,Jean Kwun,Stuart J Knechtle

Journal of Immunological Methods（2022）

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摘要

This study describes the first in vitro nonhuman primate model of B cell activation and proliferation using both naïve and allosensitized samples. This model provides an opportunity for exploration of B cell mechanisms and novel therapeutics and is a preliminary step in the development of an in vitro germinal center model.

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关键词

B cell culture,Nonhuman primate,Alloantibody,Plasmablast,Cell culture

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