Limited Impact of First-Line Drug Resistance Mutations on Virologic Response Among Patients Receiving Second-Line Antiretroviral Therapy in Rural Uganda.

David M Moore,Mastula Nanfuka,Wendy Zhang,Steven Okoboi,Pontiano Kaleebu,Anne Kapaata,Julia Zhu,Baker Tibengana,Josephine Birungi

Journal of acquired immune deficiency syndromes (1999)（2023）

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摘要

Even in the presence of multiple DRMs on first-line therapy, virologic failure after 3 years of protease inhibitor-based ART was infrequent. Suboptimal adherence to ART was associated with virologic failure.

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关键词

antiretroviral therapy,sub-Saharan Africa,drug resistance,nonnucleoside reverse transcriptase inhibitors,treatment failure

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