The PDE5 inhibitor, vardenafil, ameliorates progressive pathological changes in a focal segmental glomerulosclerosis mouse model

Su-Wei Hu,Yuan-Hung Wang,Jhy-Shrian Huang,Yea-Mey Yang,Chia-Chang Wu,Chao-Wen Cheng

Life Sciences（2022）

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摘要

Our data suggest that VAR exhibited reno-therapeutic effects via attenuating podocyte loss, preserving the integrity of the glomerular vasculature, and ameliorating fibrotic changes. These findings suggest that PDE5is might be a promising treatment modality for nephrotic syndrome.

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关键词

Focal segmental glomerulosclerosis,Nephrotic syndrome,Podocyte injury,Endothelial cell,Epithelial-to-mesenchymal transition

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