Effect of Irisin on Human Nucleus Pulposus Cells: New Insights into the Biological Cross-talk Between Muscle and Intervertebral Disk.

Gianluca Vadalà,Giuseppina Di Giacomo,Luca Ambrosio,Claudia Cicione,Veronica Tilotta,Fabrizio Russo,Rocco Papalia,Vincenzo Denaro

Spine（2023）

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摘要

Irisin increases hNPC proliferation, GAG content, metabolic activity, and promotes anabolic gene expression while reducing catabolic markers. Irisin may be one of the mediators by which PE and muscle tissues modulate IVD metabolism, suggesting the existence of a biological cross-talk between the muscle and IVD.

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关键词

intervertebral disk,irisin,muscle,physical exercise,nucleus pulposus

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