Antigen presentation by Follicular Dendritic cells to cognate B cells is pivotal for Generalised Modules for Membrane Antigens (GMMA) immunogenicity

•The humoral immune response elicited by GMMA is independent on the TLR2 engagement.•The absence of TLR4 engagement negatively affects the anti-GMMA antibody production, but the impact on antibody functionality is dependent on the GMMA type and the presence of Alum adjuvant.•The disruption of antigen presentation by FDC to cognate B cells negatively affects both antibody production and functionality when immunizing with GMMA, in absence or presence of Alum adjuvant.•The immunological mechanisms of GMMA immunogenicity has been studied by using mutant mice in which the mechanisms under investigation were disrupted.