Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis

Robert L Barry,Angel Torrado-Carvajal,John E Kirsch,Grae E Arabasz,Daniel S Albrecht,Zeynab Alshelh,Olivia Pijanowski,Austin J Lewis,Mackenzie Keegan,Beverly Reynolds,Paulina C Knight,Erin J Morrissey,Marco L Loggia,Nazem Atassi,Jacob M Hooker,Suma Babu

NeuroImage: Clinical（2022）

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摘要

•Participants with ALS exhibited atrophy of the cervical enlargement in the spinal cord.•We did not observe similar evidence of atrophy of the thoracolumbar enlargement.•Spinal cord atrophy at vertebral levels C4 to C7 is a potential imaging marker for quantifying lower motor neuron degeneration in ALS.

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关键词

Atrophy,Cross-sectional area,Cervical enlargement,Spinal cord,Magnetic resonance imaging,Amyotrophic lateral sclerosis

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